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BiTE antibodies work by bispecific binding
For the design of BiTE antibodies, Micromet uses just the small binding domains by which antibodies recognize their antigens on T cells (green) or target cells (red). In a BiTE antibody, all domains are linked together on one polypeptide chain using Micromet's proprietary single-chain antibody technology. BiTE antibodies can be produced in mammalian cell culture systems as fully functional proteins with high stability and homogeneity.