BiTEŽ Antibody Platform
How a BiTE Antibody Works
Scientific Publications
Blinatumomab (MT103) and Other BiTE Antibodies
Adecatumumab (MT201)
and EpCAM Target
MT203 & MT204
MT293 (TRC093)
New Antibody Constructs
and Target Discovery
Scientific Conferences
 
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MT203 & MT204

Combined blockade of GM-CSF and IL-17 pathways potently suppresses chronic destructive arthritis in a TNF{alpha}independent mouse model
Plater-Zyberk, C. et. al. Ann Rheum Dis. May 21, epub ahead of print (2008)

Abstract

Lipopolysaccharide-induced lung inflammation is inhibited by neutralization of GM-CSF
Puljic, R. et al. Euro J. Pharmcol557:230-235 (2007) 

Abstract

GM-CSF neutralization suppresses inflammation and protects cartilage in acute streptococcal cell wall arthritis of mice
Plater-Zyberk, C. et al. Annals Rheumatic
Disease
66: 452-7 (2007)

Abstract
A human monoclonal IgG1 potently neutralizing the pro-inflammatory cytokine GM-CSF
Krinner, E.M. et al. Mol. Immunol. 44: 916-925 (2007)
Abstract

A humanized monoclonal antibody against interleukin-2 that can inactivate the cytokine/receptor complex
Volkland, J. et al.  Mol. Immunol. 44: 1743-1753 (2007)

Abstract
A highly stable polyethylene glycol-conjugated human single-chain antibody neutralizing granulocyte/macrophage colony stimulating factor at low nanomolar concentration
Krinner, E.M. et al. Protein Egineering, Design and Selection 19: 461-470 (2006)
Abstract
 
   
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