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Adecatumumab (MT201) and EpCAM Target
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Inhibition of breast cancer cell proliferation and unique epitope recognition by EpCAM-specific human monoclonal antibody adecatumumab Muenz, M. et. al. Annual Meeting of AACR Abstract No. 5339 (2010) |
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Overexpression of EpCAM in uterine serous papillary carcinoma: Implications for EpCAM-specific immunotherapy with human monoclonal antibody adecatumumab (MT201) El-Sahwi, K. et. al. Mol Cancer Ther 9: 57–66 (2010) |
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The emerging role of EpCAM in cancer and stem cell signaling Muenz, M., Baeuerle, P. A., Gires, O. Cancer Res 69: 5627-5629 (2009) |
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Potential therapeutic activity of adecatumumab (MT201), a fully human monoclonal antibody, against epithelial cell adhesion molecule (EpCAM) in uterine serous papillary carcinoma Santin, A. et. al. J Clin Oncol 27: Abstract No. e16502 (2009) |
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EpCAM’s renaissance Baeuerle, P.A. and Ruettinger, D. Drug Discovery & Development, www.dddmag.com, April 9 (2009) |
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Nuclear signalling by tumour-associated antigen EpCAM Maetzel, D. et. al. Nat Cell Biol 11: 162-171 (2009) |
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Rationale for treatment of colorectal cancer with EpCAM targeting therapeutics Baeuerle, P.A., Riethmueller, G. In: Tumor-associated antigens: identification, characterization and clinical application (Gires, O., Seliger, B., eds.) Wiley-VHC, Weinheim, pp. 179-200 (2009) |
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On the abundance of EpCAM on cancer stem cells Gires, O. et. al. Nature Reviews Cancer Jan. 9, epub ahead of print (2009) |
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First results from a phase Ib study of the anti-EpCAM antibody adecatumumab (MT201) in combination with docetaxel in patients with metastatic breast cancer Schuler, M. et. al. Annual Meeting of ESMO, Abstract No. 485p (2008) |
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Nuclear signalling by tumour- and stem cell-associated antigen EpCAM (CD326) Gires, O. et al. Annual Meeting of AACR-NCI-EORTC Abstract No. C175 (2007) |
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Apparent lack of immunogenicity of human antibody adecatumumab in breast and prostate cancer patients Wolf, A. et al. Annual Meeting of AACR-NCI-EORTC Abstract No. B49 (2007) |
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Highly reduced incidence of new breast cancer metastases during treatment with adecatumumab appears to be the major factor for longer time to tumor progression in patients with high-level EpCAM expression Dittrich, C. et al. Annual Meeting of AACR-NCI-EORTC Abstract No. A71 (2007) |
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EpCAM (CD326) – finding its role in cancer Baeuerle, P.A. and Gires, O. Brit J Cancer 96: 417-423 (2007) |
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Exchanging human lg gamma 1 with murine lg gamma 2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung cancer model Lutterbuese, P. et al. Cancer Immunol Immunother 56: 459-468 (2007) |
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Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer Spizzo, G. et al. Gynecol Oncol 103: 483-488 (2006) |
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A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients Oberneder, R. et al. Eur J Cancer 42: 2530-2538 (2006) |
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Frequent high-level expression of immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung carcinomas Went, P. et al. Brit J Cancer 94 :128-135 (2006) |
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Expression of epithelial cellular adhesion molecule (Ep-CAM) in chronic (necro-) inflammatory liver diseases and hepatocellular carcinoma Breuhahn, K. et al. Hepatology Research 34: 50-56 (2006) |
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High concentrations of therapeutic antibodies are needed to compensate for inhibition of antibody-dependent cellular cytotoxicity by excess immunoglobulin G Preithner, S. et al. Mol Immunol 43: 1183-1193 (2006) |
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Cellular and complement-dependent cytotoxicity of monoclonal antibody MT201 against human breast cancer cell lines Prang, N. et. al. Brit J Cancer 92: 342-349 (2005) |
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Cytotoxic activity of novel monoclonal antibody MT201 against primary ovarian tumor cells Xiang, W. et al. J Canc Res Clin Oncol 129: 341-348 (2003) |
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In-vitro and in-vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment Naundorf, S. et al. Int J Cancer 100: 101-110 (2002) |
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